2014-03-24 19:10:33 - Ralph Tripp, U of Georgia, to Speak at Non-Coding RNAs and RNAi Conf., June 19-20, 2014, SD, CA
Ralph Tripp, University of Georgia, will speak at the Non-Coding RNAs and RNAi Research & Therapeutics Conference, to be held June 19-20, 2014 in San Diego, CA.
Despite the critical role that vaccines have in preserving public health, cost and manufacturing challenges prevent a significant portion of the world’s population from accessing these life-saving preventative medicines. Recent advances in RNAi and gene modulation open the prospect of creating a new generation of engineered cell lines with enhanced vaccine manufacturing capabilities.
Dr. Tripp, a Professor and the Georgia Research Alliance Chair in Vaccine and Therapeutic Studies, will share how his lab has performed a genome-wide RNAi screen to identify gene knockdown events that enhance poliovirus replication. Primary screen hits were subsequently
validated with poliovirus strains and cell lines employed in vaccine production to ensure the observed increases in viral titers were broadly applicable to vaccine manufacturing platforms. Finally, the lab created stable knockout cell lines capable of enhance vaccine production. This approach of modulating host gene expression profiles to increase virus production has the potential to address global health by significantly enhancing vaccine production at reduced costs.
For more information about the conference, please visit www.gtcbio.com/rna