2009-05-13 13:01:43 - CPG-Based Pipette tip columns offer consistently high-performance and reproducibility

ASTON, Pennsylvania – 3Prime has today announced its new range of innovative pipette tip columns that are designed to work with leading oligonucleotide synthesizer instruments, such as the ABI Model 3900 Synthesizer. These columns are available with two different solid supports; either a controlled porosity glass (CPG) or a proprietary low-swelling polystyrene for greater flexibility. Both types of columns are

available for three different synthesis scales: 50 nanomoles, 200 nanomoles and 1 micromole, and are sold individually, or in batches of 200 columns.

A new, highly precise mold ensures that the pipette tip columns are made with minimal lot-to-lot variance. The quantity of CPG and polystyrene solid synthesis supports used in the columns are measured with high accuracy and are quality controlled for 3-Prime by Integrated DNA Technologies (IDT) in actual oligonucleotide synthesis tests. This results in very consistent column performance, both in terms of high synthesis yield and high purity oligonucleotide products. More importantly, the solution flow characteristics of these columns allow them to be used with no modification to the synthesizer software protocols.

Marc Rothstein, President of 3Prime commented, “3Prime saw an excellent opportunity to provide customers using one of the most popular synthesis platforms with the best products in the industry.” He continued, “The performance and cost of our columns have benefited our extensive development efforts to improve controlled porosity glass as a synthesis solid support. Our new GMP facility and quality control programs result in columns that give the consistently high performance and reproducibility that researchers need. Each batch of nucleoside CPG is synthesis tested to ensure successful syntheses for every oligonucleotide applications.”

For more information visit www.3prime.com.

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