2013-03-19 08:36:47 - Paloma Giangrande, Assistant Professor at the University of Iowa, will present on “Targeted Image-Guided RNA Therapies” at the 4th RNAi Research & Therapeutics Conference on June 20-21, 2013 in San Francisco, CA.
Recent clinical trials of small interfering RNAs (siRNAs) have highlighted the need for robust delivery techniques that will enable the application of this therapeutic to humans. Cell conjugation of siRNAs to cell-specific ligands provides a viable solution to this problem, and synthetic RNA ligands (aptamers) represent an emerging class of pharmaceuticals with great potential for targeted therapeutic and diagnostic applications.
However, the extended use of RNA aptamers as a delivery tool for siRNAs cannot be fully utilized until RNA aptamer sequences that are capable of targeting and entering the cytoplasm of many different cell types are identified.
Dr. Giangrande will discuss novel selection methodologies for the rapid identification and characterization of RNA aptamers capable of delivering siRNAs into the cytoplasm of
target cells. Her research has coupled these methodologies with state-of-the-art RNA chemistries and fluorescent technologies, resulting in effective, targeted image-guided RNA (TIGR) reagents that can be easily tracked in vivo. Most importantly, these TIGRs may represent a crucial first step in the transition of siRNAs from the bench-side of research and into the clinic.
Paloma H. Giangrande, PhD, is an Assistant Professor in the Department of Internal Medicine at the University of Iowa. The long-term research goals of Dr. Giangrande’s laboratory are to develop RNA-based tools to modulate cellular pathways underlying pathological cell proliferation in the setting of cancer and cardiovascular disease. Her emerging interests include the development of diagnostic tools for imaging cancers and cardiovascular disease in vivo. In May 2013, she will receive the American Society of Gene and Cell Therapy’s Young Investigator Award at the ASGCT’s annual meeting.
GTC’s 4th RNAi Research & Therapeutics Conference will provide a forum for leaders from both academia and industry to share their perspective and progress in RNA delivery and validation applications and network with fellow scientists and principle investigators to discuss the future of RNA-related discovery.
To view the agenda, click here.
To view the speaker list, click here.
The conference is part of the Nucleic Acid Summit 2013, which includes two other exciting meetings:
Bioinformatics & Data Management Strategies Workshop
3rd Next-Generation Sequencing Conference
For more information, please visit www.gtcbio.com/rnai