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Medigene Announces Results from Investigator Initiated Trial of EndoTAG®-1 to be Published for ASCO 2013

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2013-04-11 07:33:57 -

Medigene AG /
Medigene Announces Results from Investigator Initiated Trial of EndoTAG®-1 to be 
Published for ASCO 2013 
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The issuer is solely responsible for the content of this announcement. 

Martinsried/Munich, April 11, 2013. Medigene AG (Frankfurt, Prime Standard; MDG)
announced  today that the results from  the Phase 2 investigator initiated trial
(IIT)  of EndoTAG(®)-1 in HER2-negative breast cancer  will be published for the
upcoming Annual Meeting of the American Society of Clinical Oncology (ASCO). The
abstract   (#114428),   entitled   "Feasibility   study  of  cationic  liposome-
encapsulated  paclitaxel  in  combination  with  paclitaxel  followed  by FEC as
induction  therapy  in 
HER2-negative breast cancer" was chosen for inclusion online in the ASCO 2013 Annual Meeting Proceedings, a Journal of Clinical Oncology supplement, and will be released at on May 15, 2013. The investigator initiated trial with EndoTAG(®)-1 was conducted by Prof. Dr. Ahmad Awada, Head of the Medical Oncology Clinic at the Institut Jules Bordet in Brussels, Belgium, and principal investigator in the previously conducted EndoTAG(®)-1 phase II trial in locally relapsed and/or metastatic advanced Triple Negative Breast Cancer (TNBC). The aim of the exploratory open-label Phase 2 IIT was to evaluate the efficacy and safety of neoadjuvant EndoTAG(®)-1 in combination with paclitaxel in patients with HER2-negative breast cancer. About EndoTAG(®)-1: EndoTAG(®)-1 is a novel composition of the established cytostatic drug paclitaxel combined with neutral and positive lipids. The positively charged lipids imply that EndoTAG(®)-1 interacts with newly developed, negatively charged endothelial cells, which are primarily required for the growth of tumor blood vessels. The EndoTAG(®)-1 paclitaxel component attacks the endothelial cells as they divide, thus targeting the blood supply to tumors without affecting the supply to healthy tissue. By doing this, EndoTAG(®)-1 is expected to prevent the formation of new tumor blood vessels and to inhibit tumor growth. Medigene has successfully completed two clinical phase II trials of EndoTAG(®)-1 in the indications pancreatic cancer and triple- negative breast cancer (TNBC). Medigene AG (Frankfurt: MDG, prime standard) is a publicly listed biotechnology company headquartered in Martinsried/Munich, Germany. Medigene focuses on clinical research and development of novel drugs against cancer and autoimmune diseases. Medigene is the first German biotech company to have revenues from a marketed product (Veregen(®)), which is distributed by partner companies. Medigene has two drug candidates in clinical trials, EndoTAG(®)-1 and RhuDex(®), and is developing an innovative vaccine technology. For more information, please visit This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene(®) and Veregen(®) are registered trademarks of Medigene AG. Polyphenon E(® )is a trademark of Mitsui Norin Co., Ltd. These trademarks may be owned or licensed in select locations only. Contact Julia Hofmann, Claudia Burmester Investor & Public Relations Tel.: +49 - 89 - 20 00 33 - 33 01 Email: To unsubscribe from the press release distribution list, please go to Press release as PDF: This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients. The owner of this announcement warrants that: (i) the releases contained herein are protected by copyright and other applicable laws; and (ii) they are solely responsible for the content, accuracy and originality of the information contained therein. Source: Medigene AG via Thomson Reuters ONE [HUG#1692200]

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