The 'Break-Up' actress beat 'Dukes of Hazzard' actress Jessica Simpson and singer Christina Aguilera to the coveted title, in a study carried out by electronics giant Braun.
Scientists came up with a specific formula, which involves multiplying the proportions of the leg and thigh, and the texture of skin, to calculate the perfect pair of pins.
Due to the "ideal" proportions of her legs and her smooth skin, Aniston scored an impressive 14.67, the highest score of anyone tested.
Dr Aric Sigman, who conducted the study, said: "For men, the ideal leg is shapely, full and smooth with a semi-gloss sheen. Women want the same thing - only two sizes smaller." The study also showed most British men preferred women to have more shapely legs like curvy Beyoncé Knowles.
A Braun spokeswoman said: "It shows that women are much too hard on themselves."