The Oscar-winning actor insists he "needs" to use the word but believes white people shouldn't be allowed to.
Jamie - who was referring to 'Seinfeld' actor Michael Richards' racist outburst at Los Angeles' Laugh Factory - said: "He was just calling us n****r like it was the 50s! Then they said we can't use the word anymore.
That's my s**t. I need it.
"I need the word to describe certain things, because at a certain level of excitement, I need to tell you how the s**t was, and there ain't no other word that helps me say that better than that word.
"White people, you can't use it. I would have booked his ass!" The 39-year-old actor also said he wishes he had been adopted by Angelina Jolie.
Jamie, who delivered his comedy monologue at Atlantic City's Borgata Hotel on Sunday (14.01.07), said: "You know your famous when you can just go over to another country and pick up some kids like you're shopping for vegetables.
"I wish she was adopting when I was coming up. I would have breast-fed till I was 37!"