2008-11-14 12:02:03 -

Research and Markets (cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww ..) has announced the addition of John Wiley and Sons Ltd's new report "Dopamine Transporters : Chemistry, Biology, and Pharmacology" to their offering.
Understanding the dopamine transporter can lead to new therapies for neurological disorders
This book consolidates current information on the dopamine transporter (DAT) in relation to medicinal chemistry and synthesis, biology

and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.
This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology:
- Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization
- Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers
- Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods
This is a hands-on reference for researchers, medicinal chemists, pharmacologists, and biologists working with DAT or related proteins and for students in related areas of study.
Key Topics Covered:
Part I: Biochemistry and Molecular Biology.
- The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino).
- Dopamine Transporter, Disease States and Pathology (Deborah C. Mash).
- Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh).
- Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan).
- Electrochemical characterization of dopamine transporters (Evgeny A. Budygin and Sara R. Jones).
Part II: Medicinal Chemistry.
- Tropane-based dopamine transporter-uptake inhibitors (Scott P. Runyon and F. Ivy Carroll).
- The Benztropines: Atypical Dopamine-Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (Amy Hauck Newman and Jonathan L. Katz).
- Structure-Activity relationship of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice).
- Structure-activity relationship study of piperidine derivatives for dopamine transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta).
- Non-Nitrogen-containing dopamine transporter-uptake inhibitors (Peter C. Meltzer).
- Dopamine-Releasing Agents (Bruce E. Blough).
Part III: Pharmacology.
- PET/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter. (Paul Cumming, Weiguo Ye, Dean F. Wong).
- In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser).
- In vivo studies of dopamine transporter function (Jane B. Acri).
For more information visit cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww ..
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